They induce "checkpoint proteins" like PD-1 to inhibit immune responses

– This works for hot tumors, but the immunotherapy can have adverse effects

They turn off internal  “danger” pathways that “alarm” the immune system 

 ADAR binds to flipons that negatively regulate these type I interferon responses

– ADAR is druggable with a small molecule with active programs at many companies


They  label themselves “super-self”  to disguise mutant proteins as normal

– InsideOutBio uses the complement pathway to  turn tumor antigens immunogenic

– It does so without the risk of autoimmunity against normal proteins

– It’s approach is foundational for the treatment of cold tumors

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